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Health-Related Quality of Life Among Drug-Naïve Patients with Narcolepsy with Cataplexy, Narcolepsy Without Cataplexy, and Idiopathic Hypersomnia Without Long Sleep Time

Published Online:https://doi.org/10.5664/jcsm.27352Cited by:72

ABSTRACT

Objective:

To evaluate the health-related quality life (HRQOL) of drugnaïve patients with narcolepsy with cataplexy (NA with CA), narcolepsy without cataplexy (NA without CA) and idiopathic hypersomnia without long sleep time (IHS without LST), and to explore the factors influencing the HRQOL. Factors associated with the occurrence of automobile accidents are also discussed.

Methods:

A total of 137 consecutive drug naïve patients who met the criteria of the 2nd edition of the International Classification of Sleep Disorders (NA with CA, n = 28; NA without CA, n = 27; IHS without LST, n = 82) were enrolled. The patients were asked to fill out questionnaires, including the SF-36, Epworth Sleepiness Scale (ESS), sociodemographic variables, and items regarding driving habits and the experiences related to automobile accidents.

Results:

All 3 diagnostic groups had significantly lower scores in most SF-36 domains compared with Japanese normative data. Significant differences among the 3 diagnostic groups were not observed. Specific factors in SF-36 domains were not found with multiple linear regression analyses, while disease duration was positively correlated with mental health among all subjects. Among the patients reporting driving habits, ESS score (≥16) was positively associated with the experience of automobile accidents.

Conclusions:

Our results indicated that HRQOL decreases in drugnaïve patients with hypersomnia, but neither disease category nor severity of the disorder appears as an associated factor. Increased severity of hypersomnia, however, was thought to play an important role in the occurrence of automobile accidents.

Citation:

Ozaki A; Inoue Y; Nakajima T; Hayashida K; Honda M; Komada Y; Takahashi K. Health-related quality of life among drug-naïve patients with narcolepsy with cataplexy, narcolepsy without cataplexy, and idiopathic hypersomnia without long sleep time. J Clin Sleep Med 2008;4(6):572-578.

INTRODUCTION

Hypersomnia, a complaint of excessive daytime sleep or sleepiness, affects 9% to 17% of the general population,14 with an impact on the functions of daily life. Some previous studies provided the data suggesting that patients with narcolepsy suffer from severe limitations and difficulties in everyday life activities (school, job, interpersonal relationships, and social activities).5,6 Studies using the 36-item short from (SF-36) showed that health-related quality of life (HRQOL) among patients with hypersomnias of central origin, especially narcolepsy, decreases in comparison to the general population.711

In the 2nd edition of the International Classification of Sleep Disorders (ICSD-2),12 narcolepsy was classified into 2 categories focusing on the existence of cataplexy (i.e., narcolepsy with cataplexy [NA with CA] and without cataplexy [NA without CA]). Idiopathic hypersomnia without long sleep time (IHS without LST), also known as NREM narcolepsy or essential hypersomnia, manifesting hypersomnolence similar to narcolepsy without REM sleep abnormality, was also classified as an independent category. Most studies related to HRQOL in patients with hypersomnia have been done on narcoleptic patients with and without psychostimulant medication, and no study has been conducted focusing on untreated patients in the above 3 diagnostic groups711 Moreover, conclusive information about the association between clinical backgrounds and the impairment of HRQOL in these drug-naïve patients has not been obtained.

Excessive daytime sleepiness (EDS) while driving or performing other activities that require constant alertness is dangerous. Narcolepsy has marked effects on daytime performance and has been associated with an increased risk of automobile accidents, as well as accidents on the job and at home.13,14 However, a relationship between the subjective severity of sleepiness and the occurrence of automobile accidents in the drugnaïve patients has not been elucidated.

The aims of the present study were as follows: (1) to evaluate HRQOL of drug-naive patients with NA with CA, NA without CA, and IHS without LST; (2) to explore the factors influencing HRQOL; and (3) to clarify the association between clinical background factors including severity of sleepiness and occurrence of automobile accidents.

METHODS

The present study was approved by the local ethics committee of the Japan Somnology Center. Informed consent was obtained from all the patients who participated in the study.

Participants

Among patients ≥ 20 years who visited the outpatient clinic of the Japan Somnology Center seeking medical assistance, 137 consecutive drug-naïve patients with a diagnosis of NA with CA (n = 28), NA without CA (n = 27), or IHS without LST (n = 82) who met the criteria of ICSD-212 were enrolled between May 2003 and October 2004. Because of an insufficient number of patients, IHS with LST was not targeted in the present study. All subjects with NA without CA and IHS without LST underwent overnight polysomnography followed by a standard multiple sleep latency test (MSLT).15 Among the subjects with NA with CA, 7 did not undergo MSLT, but each had a history of typical cataplexy and clear sleep onset REM periods during overnight polysomnography. The 21 remaining subjects with NA with CA and all the subjects with NA without CA had ≥ 2 SOREMP and < 8 min mean sleep latency on MSLT. All subjects with IHS without LST showed ≤ 8 min of mean sleep latency and 0–1 SOREMP on MSLT. Diagnoses were made according to the above criteria by at least 2 board-certified sleep disorder expert psychiatrists. Patients with comorbidities of other sleep disorders (e.g., obstructive sleep apnea syndrome, periodic limb movement disorder, circadian rhythm sleep disorders), psychiatric disorders (including mood disorders) and other major medical illnesses, and patients taking sedatives habitually were completely excluded from this study.

Measures

The participants were asked to fill out a questionnaire that included an instrument assessing dimensions of HRQOL, an instrument evaluating subjective sleepiness, questions regarding sociodemographic variables, and items regarding driving habits and the experiences of automobile accidents. Additional clinical information including demographic variables was also obtained from the participants' medical records.

Medical Outcomes Study Short Form-36 Version 1.2

HRQOL was assessed by using the Japanese version of the Short Form-36 health survey questionnaire (SF-36, Ver. 1.2), a self-administered questionnaire that has been widely used and validated on Japanese general population.1618 The questionnaire comprises 36 questions divided into the following 8 domains representing different aspects of HRQOL.

  1. Physical functioning (PF), the subject's ability to deal with the physical requirement of life, such as attending to personal needs, walking, and flexibility.

  2. Role limitations due to physical problems (RP), the extent to which physical capabilities limit activity.

  3. Role limitations due to emotional problems (RE) the extent, if any, to which emotional factors interfere with work or other activities.

  4. Social functioning (SF), the extent to which physical health or emotional problems have interfered with family, friends, and other social interactions during the previous 4 weeks.

  5. Mental health (MH), feelings of anxiety and depression.

  6. Energy/vitality (VT), feelings of pep, energy, and fatigue.

  7. Bodily pain (BP), perceived amount of pain experienced during the previous 4 weeks and the extent to which that pain interfered with normal work activities.

  8. General health perceptions (GH), general health in terms of personal perception.

Epworth Sleepiness Scale

Subjective sleepiness was assessed at the time of the first visit, using the Epworth Sleepiness Scale (ESS),19 a widely accepted self-completion questionnaire, previously validated on both the Japanese general population and patients with hypersomnia.20 Participants were asked about the possibility of falling asleep in 8 specific situations that are commonly encountered in daily life (0 = would never doze; 3 = high chance of dozing). The ESS score is the sum of 8 item-scores and can range from 0 to 24.19 The severity of subjective sleepiness was defined by the ESS score: normal (ESS score < 11), mild (≥ 11, < 16) and severe (≥ 16).2123

Sociodemographic Variables, Automobile Accidents, and Clinical Information

Sociodemographic variables included marital status, numbers of family members in the household, educational status, and occupation. Questions about driver's license, driving habit, and the experience of automobile accidents were embedded: “Have you ever been involved in automobile accidents or nearmiss incidents while driving during the last 5 years?” Clinical information including age, gender, age at onset of hypersomnia, and length of its morbidity was also obtained.

Statistical Analysis

Demographic, sociodemographic and clinical variables were compared among three diagnostic groups (NA with CA, NA without CA, and IHS without LST). One-way analysis of variance (ANOVA) was used for the comparison of the continuous variables among the 3 diagnostic groups, and the chi-squared test was employed for categorical variables.

The scores of 8 subscales of the SF-36 were converted into Japanese norm-based score according to their gender and age (standardized t score transformation with a mean of 50 ± 10).18 Scores below 50 indicate that health status is below average compared to the general Japanese population. This method enables comparison of the magnitude of impact among the 8 subscales, which reflects the recommendation of Japanese Manual of SF-36.18 The scores of all subjects were compared with those of the national normative scores among each diagnostic group by using Welch's test. Multiple linear regression analyses were performed to identify the factors associated with HRQOL as measured by the SF-36 scores among each diagnostic group. Gender (female/male), age, disease duration, and the ESS score were set as the independent variables.

After evaluating the rates of the patients with experiences of automobile accidents or near-miss incidents, multiple logistic regression analyses were performed to explore the factors associated with the occurrence of these accidents or near-miss incidents among the subject patients. The dependent variable was the experience of the occurrence of these accidents or nearmiss incidents, which were dichotomized for analysis (accident or near-miss incident / none). The independent variables were gender, age, disease duration, the diagnostic group, and the ESS score (normal / mild / severe).

Multiple linear regression analysis was performed to clarify the contribution of single covariates, including the experience of automobile accidents or near-miss incidents, to the SF-36 scales score among the subject patients having usual driving habits. Gender, age, disease duration, the diagnostic group, ESS score, and the experience of automobile accidents or near-miss incidents were set as the independent variables. Four participants who did not have a driver's license, 49 without usual driving habits, 2 who did not answer the question about the experience of accidents, and 2 who did not answer the item about a driver's license were excluded from the analysis about the accidents. As a result, 80 current drivers were included in the accident analyses.

RESULTS

The descriptive variables for the main demographic and clinical features of the patients in each diagnostic group are shown in Table 1. Of 137 participants, 51.8% were female. The age range was 20 years to 61 years, with a median of 28 years. Demographic and clinical variables did not differ statistically among the 3 diagnostic groups except for marital status, the mean sleep latency on MSLT, and the ESS scores. Residual analysis revealed that the rates of married patients were significantly higher in IHS without LST (p < 0.01), and were significantly lower in NA without CA (p < 0.05). ANOVA showed that the mean sleep latency on MSLT differed significantly among the 3 diagnostic groups (F 2,127 = 8.44, p < 0.001). Scheffe's post hoc test revealed that the mean sleep latency in the NA with CA group was significantly shorter than that of IHS without LST (p = 0.001). ANOVA also showed that the ESS scores differed significantly among the 3 diagnostic groups (F 2,134 = 7.53, p < 0.001). Scheffe's post hoc test revealed that the ESS scores in the NA with CA group were significantly higher than that of the other 2 groups (NA with CA vs. NA without CA, p = 0.012; NA with CA vs. IHS without LST, p < 0.001). Residual analysis revealed that the rates of patients with ESS scores between 16 from 24 were significantly higher in NA with CA (p < 0.01).

Table 1 Descriptive Variables Including Main Demographic and Clinical Features and Prevalence of Automobile Accidents in Each Diagnostic Group

CharacteristicsOverallNA with CANA without CAIHS without LSTp value
Number of participants137282782
Gender (%)
    Male48.235.737.056.1n.s.
    Female51.864.363.049.3
Age (years)
    Mean ± SD31.2 ± 9.233.2 ± 13.028.6 ± 8.631.4 ± 7.6n.s.
    Median (range)28 (20–61)28.5 (21–61)26 (20–57)29 (21–59)
Age at onset (years)
    Mean ± SD18.6 ± 6.718.8 ± 7.017.8 ± 4.218.8 ± 7.2n.s.
    Median (range)18 (8–55)18 (10–38)18 (11–27)17 (8–55)
Disease duration (years)
    Mean ± SD12.6 ± 8.514.4 ± 12.311.0 ± 8.712.5 ± 6.6n.s.
    Median (range)11 (1–50)11.5 (2–50)8.5 (2–39)12 (1–29)
Marital status (%)
    Married26.317.911.134.10.033
    Not married73.782.188.965.9
Number of family menbers (%)
    ≥ 160.675.040.762.2n.s.
    032.821.448.131.7
    missing6.63.611.16.1
Education (%)
    Junior high school17.525.025.912.2n.s.
    Vocational school19.014.318.520.7
    College or higher59.157.155.661.0
    missing4.43.606.1
Occupation (%)
    Employed (full time)64.760.755.668.3n.s.
    Employed (part time)11.014.322.26.1
    Housewives7.410.77.46.1
    Students15.414.311.117.1
    missing1.503.72.4
Mean sleep latency on MSLT (Mean ± SD)3.1 ± 2.11.7 ± 1.62.6 ± 2.73.6 ± 1.8a< 0.001
(n = 130)(n = 21)(n = 27)(n = 82)
ESS score
    Mean ± SD14.8 ± 3.316.9 ± 2.814.5 ± 2.7b14.1 ± 3.3C< 0.001
    0–10 (%)9.50.07.413.4
    11–15 (%)46.032.155.647.60.037
    16–24 (%)44.567.937.039.0
N of having driving licence and driving habit80161450
    Trouble while driving (%) automobile accidents or near-miss incidents55.075.050.050.0n.s.

NA, narcolepsy; CA, cataplexy; IHS, idiopathic hypersomnia; LST, long sleep time; MSLT, multiple sleep latency test; ESS, Epworth Sleepiness Scale; n.s. not siginificant. a) versus NA with CA, p < 0.001, Scheffe's test. b) versus NA with CA, p = 0.017, Scheffe's test. c) versus NA with CA, p < 0.001, Scheffe's test.

Comparison of Short Form-36 with Normative Data

As a total group, the patients had significantly lower SF-36 scores in all domains except PF and BP scales than age- and gender-matched Japanese normative data.

Although the scores of all 8 subscales of the SF-36 did not differ statistically among the 3 diagnostic groups, RP, VT, and MH were significantly lower in all these diagnostic groups than normative data. The SF was significantly lower in both the patients with NA with CA and IHS without LST; RE was significantly lower in both the patients with NA without CA and IHS without LST; and GH was significantly lower in the patients with IHS without LST. In contrast, PF and BP were significantly higher in the patient group with NA with CA in comparison to normative data (Table 2).

Table 2 SF-36 Profiles of the Patients with Hypersomina by Diagnostic Groups in Comparisons with National-Norm Socres

no.overall n = 137
NA with CA n = 28
NA without CA n = 27
IHS without LST n = 82
SubscaleScale Scores§p valueScale Scores§p valueScale Scores§p valueScale Scores§p value
    PF51.2 ( 8.4)0.02353.4 ( 6.1)0.00851.4 ( 5.7)n.s.50.5 ( 9.7)n.s.
    RP36.1 (24.5)< 0.00138.7 (23.6)0.02033.0 (28.4)0.00436.2 (23.6)< 0.001
    BP51.0 (11.1)n.s.53.9 ( 9.1)0.03653.0 ( 9.7)n.s.49.4 (12.0)n.s.
    GH47.3 (10.8)0.00447.9 ( 8.2)n.s.49.0 (12.6)n.s.46.5 (10.9)0.009
    VT43.8 ( 9.7)< 0.00145.7 ( 9.4)0.02644.0 ( 9.6)0.00343.1 ( 9.9)< 0.001
    SF43.9 (12.6)< 0.00143.1 (12.0)0.00645.3 (12.7)n.s.43.7 (12.9)< 0.001
    RE36.5 (22.6)< 0.00139.9 (25.6)n.s.33.4 (22.3)0.00136.4 (21.7)< 0.001
    MH44.6 (10.6)< 0.00145.3 (11.6)0.04645.3 (11.1)0.03444.2 (10.1)< 0.001

NA, narcolepsy; CA, cataplexy; IHS, idiopathic hypersomnia; LST, long sleep time. PF, physical health; RP, role physical; BP, bodily pain; GH, general health; VT, vitality; SF, social functioning; RE, role emotional; MH, mental health; and n.s., not siginificant.

§Scale scores are made acording to norm-based scoring (standardized t score transformation with a mean of 50 ± 10), and parenthesis indicate standard deviation.

vs national-norm scores.

Factors Influencing the HRQOL

Multiple linear regression analyses showed that only disease duration was positively correlated with the ME among the total subjects (β = 0.248, p = 0.048, R2 = 0.037). In patients with NA with CA, a negative association between the RP and ESS scores was found in multiple linear regression analyses (β = −0.504, p = 0.024, R2 = 0.225). In patients with NA without CA, MH was positively associated with disease duration and being male (β = 0.960, p = 0.007, β = −0.404, p = 0.017, respectively, R2 = 0.551) (Table 3).

Table 3 Multiple Linear Regression Analyses: Contribution of Single Co-Variates to the SF-36 Scales Score by Diagnostic Groups

NA with CA
NA without CA
IHS without LST
Standardized βp valueStandardized βp valueStandardized βp value
PF
    gender
    age
    disease duration
    ESS
    R2
RP
    gender
    age
    disease duration
    ESS−0.5040.024
    R20.225
BP
    gender
    age
    disease duration
    ESS
    R2
GH
    gender
    age
    disease duration
    ESS
    R2
VT
    gender
    age
    disease duration
    ESS
    R2
SF
    gender
    age
    disease duration
    ESS
    R2
RE
    gender
    age
    disease duration
    ESS
    R2
MH
    gender−0.4040.017
    age
    disease duration0.9600.007
    ESS
    R20.551

NA, narcolepsy; CA, cataplexy; IHS, idiopathic hypersomnia; LST, long sleep time; ESS, Epworth Sleepiness Scale. PF, physical health; RP, role physical; BP, bodily pain; GH, general health; VT, vitality; SF, social functioning; RE, role emotional; and MH, mental health. Standardized β, Standardized regression coefficient. R2, Coefficient of determination.

Automobile Accident Rates and Factors Associated with Automobile Accidents

Of the 80 current drivers, 44 patients (55.0%) had experienced at least one accident or near-miss incident during the preceding 5 years (Table 1). Table 4 shows the results of the logistic regression analysis. Only ESS scores were significantly associated with increased experience of automobile accident or near-miss incident (severe; OR = 14.63, 95% CI: 1.97 to 108.67). However, the experience of automobile accidents or near-miss incidents was not associated with any SF-36 scale scores among the subject current drivers with hypersomnia.

Table 4 Correlation Between the Descriptive Variables and the Involvement of Automobile Accidents or Near-Miss Incidents Among the Subject Patients Having Usual Driving Habits, as Assessed by Logistic Regression Analysis

Crude
Adjusted
OR95%CIp valueOR95%CIp value
gender
    male
    female0.880.36–2.17n.s.0.640.22–1.90n.s.
age for every increase of one year1.030.97–1.08n.s.1.010.92–1.10n.s.
disease duration for every increase of one year1.040.98–1.10n.s.1.030.95–1.13n.s.
diagnosis
    IHS without LST
    NA with CA3.000.85–10.58n.s.1.740.40–7.57n.s.
    NA without CA1.000.31–3.27n.s.1.000.27–3.69n.s.
ESS score
    0 – 10
    11 – 154.250.76–23.81n.s.4.680.66–33.06n.s.
    16 –2412.062.12–68.540.00514.631.97–108.670.009

OR, odds ratio; 95% CI, 95% confidence interval. NA, narcolepsy; CA, cataplexy; IHS, idiopathic hypersomnia; LST, long sleep time; ESS, Epworth Sleepiness Scale. n = 80

DISCUSSION

Several studies have revealed that physical and mental components of HRQOL is decreased among the patients with insomnia2427 and among those with sleep apnea.2830 However, only a few studies have reported on HROQL of drug-naïve patients with hypersomnia, with comparison to the general population by diagnostic groups.9,10 Vignatelli et al. found that drug-naïve patients with narcolepsy (newly diagnosed narcolepsy group) showed significantly lower scores in all subscales of SF-36 except for BP, when compared with scores of the general Italian population. Beusterien et al. also assessed SF-36 in a group of patients positive for narcolepsy based on the criteria of the 1st edition of ICSD at baseline without medication in a clinical trial of modafinil, and showed that RP, VT, SF, and RE were significantly impaired in this group compared to the general US population. However, these studies did not focus on diagnostic categories (particularly the presence or absence of cataplexy in narcolepsy and idiopathic hypersomnia with or without long sleep time). The present study is the first to compare the HRQOL of consecutive drug-naïve patients with hypersomnias of central origin—divided into NA with CA, NA without CA, and IHS without LST—with national normative data, and to investigate the factors influencing the HRQOL in each diagnostic group.

In the present study, drug-naïve patients within the categories of hypersomnias of central origin, showed all domains of HRQOL to be significantly poorer than those of the Japanese population norm except for PF and BP. Interestingly, the present study showed that the HRQOL profile did not differ statistically among the 3 diagnostic groups, although patients with NA with CA presented more severe sleepiness than the other groups, demonstrated on both ESS score and mean sleep latency on MSLT. The severity of subjective sleepiness was significantly associated with RP only in the group of patients with NA with CA, but was not associated with any HRQOL domains in the total patient group. These findings suggest that the severity of subjective sleepiness does not act as a main factor for the decrease of HRQOL. The HRQOL profile of the group of NA with CA decreased in a fashion similar to that of the NA without CA group. Vignatelli et al. demonstrated that cataplexy did not show any correlation with SF-36 scales among patients with narcolepsy. These findings might indicate that the presence of cataplexy is unlikely to have an impact on the HRQOL among narcolepsy groups.

In our results, only disease duration was positively correlated with the MH among the total subjects. When multiple linear regression analyses were conducted in each diagnostic category, this tendency was significant in patients with NA without CA. This finding is in line with the previous report in which disease duration positively influenced the RP and the RE among drug-naïve patients with narcolepsy.9 Considering that the illness remains stable for several years in the majority of patients with narcolepsy,31 prolongation of morbidity might bring patients certain kinds of coping skills to manage disadvantage with the disorder.

The present study could not find common factors responsible for the decrease of SF-36 domains among 3 diagnostic groups, even in SF-36 scale scores which showed clearly lower values than that of the general population. We speculate that the decrease of HRQOL could be attributed to psychological, social, and environmental factors, such as lifestyle or social support rather than subjective sleepiness.

Several studies have reported on the risk of automobile accidents in patients with narcolepsy or idiopathic hypersomnia.14,32,33

In the present study, 55% of current drivers had at least one automobile accident or near-miss incident in the last 5 years. This finding is comparable to a study reported by Aldrich et al. in which 20% to 49% of current drivers with hypersomnia including narcolepsy or idiopathic hypersomnia had accidents, and 54% to 74% had near-miss incidents due to sleepiness.33 Early diagnosis and treatment of patients with hypersomnias of central origin is important in prevention of automobile accidents. In the present study, multiple logistic analyses revealed that severe EDS was an independent factor for the experience of accidents while driving. Further studies are needed to determine whether effective treatment of hypersomnia reduces the occurrence of automobile accidents among the patients of this category.

In our results, the experience of automobile accidents or nearmiss incidents was not associated with any SF-36 scale scores among the current drivers with hypersomnia. This finding might indicate that accidents and/or near-miss incidents themselves do not act as a associated factor for the deterioration of HRQOL among the participants with hypersomnia. However, it is possible that automobile accidents of our patients were not sufficiently serious to cause persistent damage to physiological and/ or mental function of the participants. In addition, we should consider the possibility that those who died in an accident or those who had serious handicaps due to injuries in crashes were not included in the present study.

In conclusion, the present study demonstrated impairment in the mental component but not the physical component of the HRQOL among drug-naïve patients with hypersomnias of central origin. The impact on the magnitude of impairment of HRQOL was not different among the disease categories. The aggravation of the severity of subjective sleepiness was significantly associated with the increased risk of automobile accidents. Our findings strongly support the necessity of early treatment of patients with hypersomnia. Further prospective study on larger samples should be done to establish the strategies for both improving HRQOL and preventing automobile accidents among the patients of this category.

DISCLOSURE STATEMENT

This was not an industry supported study. The authors have indicated no financial conflicts of interest.

ABBREVIATIONS

HRQOL

health-related quality of life

SF-36

36-item short form health survey

ICSD-2

2nd edition of the International Classification of Sleep Disorders

NA with CA

narcolepsy with cataplexy

NA without CA

narcolepsy without cataplexy

IHS without LST

idiopathic hypersomnia without long sleeptime

MLST

multiple sleep latency test

SOREMP

sleep onset rapid eye movement period

ESS

Epworth Sleepiness Scale

ANOVA

analysis of variance

PF

physical functioning

RP

role limitations due to physical problems

RE

role limitations due to emotional problems

SF

social functioning

MH

mental health

VT

energy/vitality

BP

bodily pain

GH

general health perceptions

REFERENCES

  • 1 D'Alessandro R, Rinaldi R, Cristina E, Gamberini G, Lugaresi EPrevalence of excessive daytime sleepiness an open epidemiological problemSleep19951838991, 7676174

    Google Scholar
  • 2 Hara C, Lopes Rocha F, Lima-Costa MFPrevalence of excessive daytime sleepiness and associated factors in a Brazilian community: the Bambui studySleep Med20045316, 14725824

    CrossrefGoogle Scholar
  • 3 Ng TP, Tan WCPrevalence and determinants of excessive daytime sleepiness in an Asian multi-ethnic populationSleep Med200565239, 16271696

    CrossrefGoogle Scholar
  • 4 Takegami M, Sokejima S, Yamazaki S, Nakayama T, Fukuhara S[An estimation of the prevalence of excessive daytime sleepiness based on age and sex distribution of Epworth Sleepiness Scale scores: a population based survey]Nippon Koshu Eisei Zasshi20055213745, 15791900

    Google Scholar
  • 5 Broughton WA, Broughton RJPsychosocial impact of narcolepsySleep199417S459, 7701199

    CrossrefGoogle Scholar
  • 6 Goswami MThe influence of clinical symptoms on quality of life in patients with narcolepsyNeurology199850S316, 9484421

    CrossrefGoogle Scholar
  • 7 Dodel R, Peter H, Spottke A, et al.Health-related quality of life in patients with narcolepsySleep Med2007873341, 17512797

    CrossrefGoogle Scholar
  • 8 Daniels E, King MA, Smith IE, Shneerson JMHealth-related quality of life in narcolepsyJ Sleep Res2001107581, 11285058

    CrossrefGoogle Scholar
  • 9 Vignatelli L, D'Alessandro R, Mosconi P, et al.Health-related quality of life in Italian patients with narcolepsy: the SF-36 health surveySleep Med2004546775, 15341892

    CrossrefGoogle Scholar
  • 10 Beusterien KM, Rogers AE, Walsleben JA, et al.Health-related quality of life effects of modafinil for treatment of narcolepsySleep19992275765, 10505821

    CrossrefGoogle Scholar
  • 11 Ervik S, Abdelnoor M, Heier MS, Ramberg M, Strand GHealth-related quality of life in narcolepsyActa Neurol Scand2006114198204, 16911349

    CrossrefGoogle Scholar
  • 12 American Academy of Sleep MedicineInternational classification of sleep disordersDiagnostic and coding manual20052nd ed.Westchester, ILAmerican Academy of Sleep Medicine

    Google Scholar
  • 13 Broughton R, Ghanem Q, Hishikawa Y, Sugita Y, Nevsimalova S, Roth BLife effects of narcolepsy in 180 patients from North America, Asia and Europe compared to matched controlsCan J Neurol Sci19818299304, 7326610

    CrossrefGoogle Scholar
  • 14 Broughton R, Ghanem Q, Hishikawa Y, Sugita Y, Nevsimalova S, Roth BLife effects of narcolepsy: relationships to geographic origin (North American, Asian or European) and to other patient and illness variablesCan J Neurol Sci1983101004, 6861006

    CrossrefGoogle Scholar
  • 15 Carskadon MA, Dement WC, Mitler MM, Roth T, Westbrook PR, Keenan SGuidelines for the multiple sleep latency test (MSLT): a standard measure of sleepinessSleep1986951924, 3809866

    CrossrefGoogle Scholar
  • 16 Fukuhara S, Bito S, Green J, Hsiao A, Kurokawa KTranslation, adaptation, and validation of the SF-36 Health Survey for use in JapanJ Clin Epidemiol199851103744, 9817121

    CrossrefGoogle Scholar
  • 17 Fukuhara S, Ware JE, Kosinski M, Wada S, Gandek BPsychometric and clinical tests of validity of the Japanese SF-36 Health SurveyJ Clin Epidemiol199851104553, 9817122

    CrossrefGoogle Scholar
  • 18 Fukuhara S, Suzukamo Y, Bito S, Kurokawa KManual of SF-36 Japanese version 1.22001TokyoPublic Health Research Foundation

    Google Scholar
  • 19 Johns MWReliability and factor analysis of the Epworth Sleepiness ScaleSleep19921537681, 1519015

    CrossrefGoogle Scholar
  • 20 Takegami M, Suzukamo Y, Wakita T, et al.Developement of a Japanese version of the Epworth Sleepiness Scale (JESS) based on Item Response TheorySleep Med(in press)

    Google Scholar
  • 21 Young T, Peppard PE, Gottlieb DJEpidemiology of obstructive sleep apnea: a population health perspectiveAm J Respir Crit Care Med2002165121739, 11991871

    CrossrefGoogle Scholar
  • 22 Johns MWSensitivity and specificity of the multiple sleep latency test (MSLT), the maintenance of wakefulness test and the epworth sleepiness scale: failure of the MSLT as a gold standardJ Sleep Res20009511, 10733683

    CrossrefGoogle Scholar
  • 23 Liu GF, Han S, Liang DH, et al.Driver sleepiness and risk of car crashes in Shenyang, a Chinese northeastern city: population-based case-control studyBiomed Environ Sci20031621926, 14631827

    Google Scholar
  • 24 Leger D, Scheuermaier K, Philip P, Paillard M, Guilleminault CSF-36: evaluation of quality of life in severe and mild insomniacs compared with good sleepersPsychosom Med2001634955, 11211064

    CrossrefGoogle Scholar
  • 25 Zammit GK, Weiner J, Damato N, Sillup GP, McMillan CAQuality of life in people with insomniaSleep199922Suppl 2S37985, 10394611

    Google Scholar
  • 26 Chesson AL, Anderson WM, Littner M, et al.Practice parameters for the nonpharmacologic treatment of chronic insomnia. An American Academy of Sleep Medicine report. Standards of Practice Committee of the American Academy of Sleep MedicineSleep199922112833, 10617175

    CrossrefGoogle Scholar
  • 27 Morin CM, Hauri PJ, Espie CA, Spielman AJ, Buysse DJ, Bootzin RRNonpharmacologic treatment of chronic insomnia. An American Academy of Sleep Medicine reviewSleep199922113456, 10617176

    CrossrefGoogle Scholar
  • 28 Briones B, Adams N, Strauss M, et al.Relationship between sleepiness and general health statusSleep1996195838, 8899938

    CrossrefGoogle Scholar
  • 29 Baldwin CM, Griffith KA, Nieto FJ, O'Connor GT, Walsleben JA, Redline SThe association of sleep-disordered breathing and sleep symptoms with quality of life in the Sleep Heart Health StudySleep20012496105, 11204058

    CrossrefGoogle Scholar
  • 30 Akashiba T, Kawahara S, Akahoshi T, et al.Relationship between quality of life and mood or depression in patients with severe obstructive sleep apnea syndromeChest20021228615, 12226024

    CrossrefGoogle Scholar
  • 31 Billiard M, Dauvillers Y, Michel BNarcolepsySleep: Physiology, investigations, and medicine2003New YorkKluwer Academic / Plenum Publishers40328

    CrossrefGoogle Scholar
  • 32 Garbarino S, Nobili L, Beelke M, De Carli F, Ferrillo FThe contributing role of sleepiness in highway vehicle accidentsSleep2001242036, 11247057

    CrossrefGoogle Scholar
  • 33 Aldrich MSAutomobile accidents in patients with sleep disordersSleep19891248794, 2595172

    CrossrefGoogle Scholar