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Volume 13 No. 08
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Emerging Technologies

Evaluation of Continuous Negative External Pressure (cNEP) for the Treatment of Obstructive Sleep Apnea: A Pilot Study

Jerrold A. Kram, MD, FAASM1; Robyn V. Woidtke, MSN, RN1; Kenneth B. Klein, MD2; Richard M. Rose, MD3
1California Center for Sleep Disorders, Alameda, California; 2Endpoint, LLC, Bainbridge Island, Washington; 3Sommetrics, Inc., Vista, California

Study Objectives:

To determine if the application of continuous negative external pressure (cNEP) is effective and safe in individuals with obstructive sleep apnea (OSA) during an overnight in-laboratory sleep study.

Methods:

A prospective, open-label pilot study in subjects with documented OSA recruited from the patient population at one sleep clinic. The intervention was application and titration of cNEP during overnight polysomnography.

Results:

Of the 15 subjects studied (mean apnea-hypopnea index [AHI] at baseline, 43.9 events/h), 13 (87%) were responders to cNEP: 9 had an excellent response (AHI < 5 events/h) and 4 had a partial response (AHI < 50% baseline and < 15 events/h). Three minor, self-limited adverse events occurred, which appeared related to contact pressure of the cNEP device on the skin.

Conclusions:

In this pilot study, cNEP appears to be safe and effective during short-term use in subjects with OSA. Further studies are warranted.

Citation:

Kram JA, Woidtke RV, Klein KB, Rose RM. Evaluation of continuous negative external pressure (cNEP) for the treatment of obstructive sleep apnea: a pilot study. J Clin Sleep Med. 2017;13(8):1009–1012.




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