Current Knowledge/Study Rationale: Sleep disturbance is common in Dravet syndrome and frequently affects quality of life for patients and their families. There are no established therapies for sleep disturbance in Dravet syndrome, and the nature of the sleep disturbance itself remains poorly characterized.
Study Impact: A subset of patients with Dravet syndrome reported dramatic clinical improvement in sleep initiation, maintenance, and quality of life when receiving melatonin. However, melatonin did not result in measurable overall improvements in total sleep or wakefulness after sleep onset. Although definitive evidence of clinical benefit for patients with Dravet syndrome and sleep disturbance was not shown, such individuals should nevertheless consider a trial of melatonin, as some individuals appear to derive dramatic benefits.