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Volume 15 No. 11
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Accepted Papers

Case Reports

Successful Treatment of Somnambulism With OROS-Methylphenidate

Milan Nigam, MD1,2; Antonio Zadra, PhD1,3; Soufiane Boucetta, PhD1; Steve A. Gibbs, MD, MSc1,2,4; Jacques Montplaisir, MD, PhD1,5; Alex Desautels, MD, PhD1,2,4
1Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, Québec, Canada; 2Department of Neurosciences, Université de Montréal, Montéeal, Québec, Canada; 3Department of Psychology, Université de Montréal, Montréal, Québec, Canada; 4Neurology Service, Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, Canada; 5Department of Psychiatry, Université de Montréal, Montréal, Québec, Canada

Somnambulism is a non-rapid eye movement sleep parasomnia with potential for significant injury as well as functional nighttime and daytime impairment. Clonazepam is frequently used as first line pharmacotherapy. However, the optimal treatment of somnambulism has not been established. In this article, we present the cases of two patients with severe somnambulism who showed a significant therapeutic response to osmotic release oral system methylphenidate (OROS-MPH). In addition to its practical therapeutic implications, this first report of the successful treatment of somnambulism with OROS-MPH may provide additional insight into the neurobiological underpinnings of this medical condition.


Nigam M, Zadra A, Boucetta S, Gibbs SA, Montplaisir J, Desautels A. Successful treatment of somnambulism with OROS-methylphenidate. J Clin Sleep Med. 2019;15(11):1683–1685.

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