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Volume 15 No. 09
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Accepted Papers

Case Reports

Vitamin B12 Deficiency: A Rare Cause of Excessive Daytime Sleepiness

Imran Khawaja, MD1; Kevin Yingling, RPh, MD2; Hazim Bukamur, MD1; Waiel Abusnina, MD2
1Section of Pulmonary Critical Care and Sleep Medicine, Department of Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia; 2Department of Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia

Excessive daytime sleepiness (EDS) is one of the leading reasons that patients present to sleep clinics. Approximately 10% to 14% of the adults report that excessive sleepiness interferes with their daily lives. Common causes of EDS include obstructive sleep apnea, sleep deprivation, circadian rhythm disorders, medication effects, psychiatric conditions especially depression, and primary hypersomnia such as narcolepsy or central idiopathic hypersomnia. Vitamin B12 deficiency is a rare cause of EDS. We are presenting a case of severe vitamin B12 deficiency as an unusual and rare cause of hypersomnia.


Khawaja I, Yingling K, Bukamur H, Abusnina W. Vitamin B12 deficiency: a rare cause of excessive daytime sleepiness. J Clin Sleep Med. 2019;15(9):1365–1367.

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