ADVERTISEMENT

Issue Navigator

Volume 15 No. 08
Earn CME
Accepted Papers





Scientific Investigations

Supplemental Oxygen for Treatment of Infants With Obstructive Sleep Apnea

Justin Brockbank, MD1; Carmen Leon-Astudillo, MD2; Datian Che, MD3; Archwin Tanphaichitr, MD4; Guixia Huang, MS2; Jaime Tomko, MD2; Narong Simakajornboon, MD2
1Children’s Hospital of Richmond at Virginia Commonwealth University, Richmond, Virginia; 2Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio; 3Shanghai Children’s Hospital, Shanghai Jiaotong University, Shanghai, China; 4Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

Study Objectives:

Supplemental oxygen has been shown to decrease the frequency of obstructive respiratory events during sleep, but may result in alveolar hypoventilation. Limited information exists on the effect of supplemental oxygen on sleep and respiratory events in infants with obstructive sleep apnea (OSA).

Methods:

We conducted a retrospective study of infants with OSA who had sleep studies performed from 2007–2012. All infants underwent a room air diagnostic sleep study (RA-PSG), followed by a sleep study while breathing supplemental oxygen via nasal cannula (O2-PSG) on a separate night. Infants with split-night studies or with inadequate sleep time were excluded.

Results:

Fifty-nine infants met criteria for entry into analysis. The mean age of infants at the time of RA-PSG was 13.0 ± 11.7 weeks and at O2-PSG was 15.4 ± 13.0 weeks. The obstructive AHI decreased from 19.7 ± 13.0 during RA-PSG to 10.6 ± 11.7 during O2-PSG (P < .001). The duration of longest obstructive apnea increased from 11.0 ± 4.2 seconds to 13.4 ± 7.4 seconds (P = .01). The lowest saturation associated with obstructive apneas increased from 80.7 ± 6.8% to 90.0 ± 6.7% (P < .001). Carbon dioxide data showed no difference in ventilation after supplemental oxygen administration. There was no significant change in the spontaneous arousal index, however, the percentage of respiratory events associated with arousal increased from 20.7 ± 11.1% to 35.7 ± 19.7% (P < .001).

Conclusions:

Infants with OSA who received supplemental oxygen had a significant decrease in the frequency of obstructive respiratory events and improved oxygenation without adverse effect on alveolar ventilation. These data suggest that supplemental oxygen may be an effective treatment for infants with OSA who are not good candidates for continuous positive airway pressure or surgery.

Citation:

Brockbank J, Leon-Astudillo C, Che D, Tanphaichitr A, Huang G, Tomko J, Simakajornboon N. Supplemental oxygen for treatment of infants with obstructive sleep apnea. J Clin Sleep Med. 2019;15(8):1115–1123.




Please login to continue reading the full article

Subscribers to JCSM get full access to current and past issues of the JCSM.

Login to JCSM

Not a subscriber?

Join the American Academy of Sleep Medicine and receive a subscription to JCSM with your membership

Subscribe to JCSM:  $125/volume year for individuals or $225/volume year for institutions to access all current articles and archives published in JCSM.

Download this article*:   $20 to access a PDF version of a specific article from the current issue of JCSM.

*Purchase of an article provides permission to access and print the article for personal scholarly, research and educational use. Please note: access to the article is from the computer on which the article is purchased ONLY. Purchase of the article does not permit distribution, electronic or otherwise, of the article without the written permission of the AASM. Further, purchase does not permit the posting of article text on an online forum or website.