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Volume 15 No. 05
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Accepted Papers

Scientific Investigations

Improvement of Parasomnias After Treatment of Restless Leg Syndrome/Periodic Limb Movement Disorder in Children

Neepa Gurbani, DO1,2; Thomas J. Dye, MD1,2,3; Kyle Dougherty, MD4; Sejal Jain, MD5; Paul S. Horn2,3; Narong Simakajornboon, MD1,2
1Division of Pulmonary and Sleep Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; 2Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, Ohio; 3Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; 4University of Cincinnati, College of Medicine, Cincinnati, Ohio; 5Department of Neurology and Pediatrics, Banner University Medical Center, Tucson, Arizona

Study Objectives:

Previous studies have shown that non-rapid eye movement (NREM) sleep parasomnias commonly coexist with restless legs syndrome (RLS) and periodic limb movement disorder (PLMD) in children, leading to speculation that RLS/PLMD may precipitate or worsen parasomnias. However, there are limited data about the effect of the treatment of RLS/PLMD on parasomnias in children. Hence, we performed this study to determine whether the treatment of RLS/PLMD with oral iron therapy is associated with improvement of parasomnias in children.


A retrospective database was created for children with RLS/PLMD who were treated with iron therapy. These participants were followed for at least 1 year at Cincinnati Children's Hospital Medical Center. All participants had ferritin level testing and were treated with iron therapy. In addition, all participants underwent polysomnography before starting iron therapy for RLS/PLMD except for one participant who was already on iron but required a higher dose. Most participants underwent polysomnography after iron therapy.


A total of 226 participants were identified with the diagnosis of RLS/PLMD. Of these, 50 had parasomnias and 30 of them were treated with iron therapy. Of the 30 participants, RLS symptoms improved in 15 participants (50%) and resolution of parasomnias was noted in 12 participants (40%) participants after iron therapy. Repeat polysomnography after iron therapy was performed in 21 participants (70%). After iron therapy, there was a significant decrease in periodic limb movement index (17.2 ± 8.8 [before] versus 6.7 ± 7.3 [after] events/h, P < .001). In addition, there were significant decreases in PLMS (24.52 ± 9.42 [before] versus 7.50 ± 7.18 [after] events/h, P < .0001), PLMS-related arousals (4.71 ± 1.81 [before] versus 1.35 ± 1.43 [after] events/h, P < .0001), and total arousals (11.65 ± 5.49 [before] versus 8.94 ± 3.65 [after] events/h, P < .01) after iron therapy.


Parasomnias are common in our cohort of children with RLS/PLMD. Iron therapy was associated with a significant improvement in periodic limb movement index, RLS symptoms, and resolution of a significant proportion of NREM sleep parasomnias, suggesting that RLS/PLMD may precipitate NREM sleep parasomnia.


Gurbani N, Dye TJ, Dougherty K, Jain S, Horn PS, Simakajornboon N. Improvement of parasomnias after treatment of restless leg syndrome/periodic limb movement disorder in children. J Clin Sleep Med. 2019;15(5):743–748.

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