Issue Navigator

Volume 15 No. 01
Earn CME
Accepted Papers

Case Reports

Sleep-Related Rhythmic Movement Disorder in Triplets: Evidence for Genetic Predisposition?

Helen K. Hayward-Koennecke, MD; Esther Werth, PhD; Philipp O. Valko, MD; Christian R. Baumann, MD; Rositsa Poryazova, MD
Department of Neurology, University Hospital of Zurich, Switzerland

Sleep-related rhythmic movement disorder (RMD) is common in very young children but rarely persists beyond childhood. Despite its high frequency, the underlying pathophysiology remains unclear. Familial occurrence is rare. Here we present monozygotic female triplets, all of them being affected by body rolling in terms of RMD. Furthermore, they all present with an additional genetic disease, cystic fibrosis, with the same documented mutation of the cystic fibrosis transmembrane conductance regulator gene (F508del-CFTR). Because all three monozygotic siblings are concordant for RMD, genetic factors may contribute to the time course of the disorder.


Hayward-Koennecke HK, Werth E, Valko PO, Baumann CR, Poryazova R. Sleep-related rhythmic movement disorder in triplets: evidence for genetic predisposition? J Clin Sleep Med. 2019;15(1):157–158.

Supplemental Material

Login to view supplemental material

Please login to continue reading the full article

Subscribers to JCSM get full access to current and past issues of the JCSM.

Login to JCSM

Not a subscriber?

Join the American Academy of Sleep Medicine and receive a subscription to JCSM with your membership

Subscribe to JCSM:  $75/volume year for individuals or $140/volume year for institutions to access all current articles and archives published in JCSM.

Download this article*:   $20 to access a PDF version of a specific article from the current issue of JCSM.

*Purchase of an electronic download of JCSM provides permission to access and print the issue/article for personal scholarly, research and educational use. Please note: access to the article is from the computer on which the article is purchased ONLY. Purchase of the article does not permit distribution, electronic or otherwise, of the article without the written permission of the AASM. Further, purchase does not permit the posting of article text on an online forum or website.