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Volume 15 No. 01
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Accepted Papers

Scientific Investigations

Cerebral Hemodynamics in Sleep Apnea and Actigraphy-Determined Sleep Duration in a Sample of the Hispanic Community Health Study/Study of Latinos

Dixon Yang, MD1; Tatjana Rundek, MD, PhD1; Sanjay R. Patel, MD, MS2; Digna Cabral, BS1; Susan Redline, MD, MPH3; Fernando D. Testai, MD, PhD4; Jianwen Cai, PhD5; Douglas M. Wallace, MD1; Phyllis C. Zee, MD, PhD6; Alberto R. Ramos, MD, MS1
1Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida; 2Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania; 3Departments of Medicine, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; 4Department of Neurology and Rehabilitation, University of Illinois at Chicago Medical Center, Chicago, Illinois; 5Collaborative Studies Coordinating Center, University of North Carolina at Chapel Hill, North Carolina; 6Department of Neurology and Center for Circadian and Sleep Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois

Study Objectives:

We sought to evaluate cerebral hemodynamics in obstructive sleep apnea (OSA) and actigraphy-defined short sleep duration using transcranial Doppler ultrasound (TCD) blood flow velocity in a subsample of Hispanics/Latinos without stroke and cardiovascular disease.


The sample consisted of consecutive participants at the Miami site of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) with overnight home sleep testing and 7 days of wrist actigraphy in the Sueño sleep ancillary study. Ninety-five participants had sleep data and TCD determined cerebral hemodynamics. We evaluated the association between OSA (apnea-hypopnea index [AHI] ≥ 5 events/h) and short sleep duration (< 6.8 hours; sample median) with cerebral blood flow velocities (CBFV) and pulsatility index (PI) for the middle cerebral (MCA) and basilar arteries (BA).


Median age was 48 years (range 20–64) with 71% females. Twenty-eight percent of the sample had OSA (AHI ≥ 5 events/h) with median AHI of 10.0 (range 5.0–51.7) events/h. In unadjusted analyses, participants with OSA had lower median CBFV in the BA (30.5 cm/s [interquartile range:10.2] versus 39.4 cm/s [13.3] P < .05), but not the MCA, whereas short sleepers had higher median vascular resistance in the MCA (PI = 0.92 [0.18] versus 0.86 [0.14] P < .05) and BA (PI = 1.0 [0.17] versus 0.93 [0.24] P < .05). After full adjustment, OSA was associated with decreased CBFV (β [SE] = −5.1 [2.5] P < .05) in the BA. Short sleep was associated with increased PI (β [SE] = 0.05 [0.02] P < .05) in the MCA.


In this sample of Hispanic/Latinos, OSA was associated with decreased daytime blood flow velocity in the BA, whereas actigraphy-defined short sleep duration was associated with increased cerebrovascular pulsatility in the MCA.


Yang D, Rundek T, Patel SR, Cabral D, Redline S, Testai FD, Cai J, Wallace DM, Zee PC, Ramos AR. Cerebral hemodynamics in sleep apnea and actigraphy-determined sleep duration in a sample of the Hispanic Community Health Study/Study of Latinos. J Clin Sleep Med. 2019;15(1):15–21.

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