Issue Navigator

Volume 14 No. 12
Earn CME
Accepted Papers

Case Reports

Evaluating Transfer of Modafinil Into Human Milk During Lactation: A Case Report

Sanjay Aurora, MD1; Nadia Aurora, MD2; Palika Datta, PhD3; Kathleen Rewers-Felkins, MS3; Teresa Baker, MD4; Thomas W. Hale, PhD3
1Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts; 2Texas Tech University Health Sciences Center School of Medicine, Amarillo, Texas; 3Department of Pediatrics, Texas Tech University Health Sciences Center, Amarillo, Texas; 4Department of Obstetrics and Gynecology, Texas Tech University Health Sciences Center, Amarillo, Texas

We present a case of a 27-year-old woman in whom idiopathic hypersomnolence was diagnosed in adolescence with adequate symptomatic control on daily dosage of 250 mg of modafinil. She maintained this dosage throughout her pregnancy and during the peripartum period, but did not breastfeed her newborn because of a lack of information on the transmission of modafinil in human breast milk. Samples of her breast milk were obtained at various times over a 24-hour period and analyzed using liquid chromatography mass spectrometry. The relative infant dose was calculated to be 5.3%, below the threshold of concern for drug passage via breast milk. This is the first reported case of modafinil transfer into human breast milk. Given the drug's use in a variety of sleep disorders, the results of this case can be used to advise breastfeeding mothers prescribed modafinil.


Aurora S, Aurora N, Datta P, Rewers-Felkins K, Baker T, Hale TW. Evaluating transfer of modafinil into human milk during lactation: a case report. J Clin Sleep Med. 2018;14(12):2087–2089.

Please login to continue reading the full article

Subscribers to JCSM get full access to current and past issues of the JCSM.

Login to JCSM

Not a subscriber?

Join the American Academy of Sleep Medicine and receive a subscription to JCSM with your membership

Subscribe to JCSM:  $75/volume year for individuals or $140/volume year for institutions to access all current articles and archives published in JCSM.

Download this article*:   $20 to access a PDF version of a specific article from the current issue of JCSM.

*Purchase of an electronic download of JCSM provides permission to access and print the issue/article for personal scholarly, research and educational use. Please note: access to the article is from the computer on which the article is purchased ONLY. Purchase of the article does not permit distribution, electronic or otherwise, of the article without the written permission of the AASM. Further, purchase does not permit the posting of article text on an online forum or website.