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Volume 14 No. 10
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Accepted Papers

Case Reports

Two Cases of Sleep-Related Eating Disorder Responding Promptly to Low-Dose Sertraline Therapy

Ranji Varghese, MD1,2; Jorge Rey de Castro, MD3,4; Cesar Liendo, MD5; Carlos H. Schenck, MD1,2,6
1Minnesota Regional Sleep Disorders Center, Minneapolis, Minnesota; 2University of Minnesota Medical School, Minneapolis, Minnesota; 3Departamento de Medicina, Escuela de Medicina, Universidad Peruana Cayetano Heredia, Lima, Perú; 4Laboratorio del Sueño Clínica Anglo Americana, Lima, Perú; 5Louisiana State University Multidisciplinary Sleep Clinic at Shreveport, Shreveport, Louisiana; 6Department of Psychiatry, Hennepin County Medical Center, Minneapolis, Minnesota

We report two cases of adult males with sleep-related eating disorder (SRED), with durations of 3 and 7 years, and without associated psychiatric history. In both cases, the use of low-dose (25 mg) sertraline taken at bedtime resulted in immediate, full and sustained resolution of symptoms at the latest follow-ups. The sertraline efficacy was of particular benefit for the patient reported on in case 2 who was a commercial airline pilot subjected to a highly restricted list of Federal Aviation Administration-approved medications. Risk factors for SRED included smoking cessation and work-related stress in case 1, and a history of sleepwalking and work-related circadian disruptions and partial sleep deprivations in case 2. Sertraline therapy of SRED is considered within a review of all current pharmacologic therapies of SRED.


Varghese R, Rey de Castro J, Liendo C, Schenck CH. Two cases of sleep-related eating disorder responding promptly to low-dose sertraline therapy. J Clin Sleep Med. 2018;14(10):1805–1808.

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