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Volume 14 No. 10
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Accepted Papers

Case Reports

Tachypnea Seen During Positive Airway Pressure Titration Studies: A Case Series of Four Patients

Amit Gupta, MD; Timothy Roehrs, PhD; Kenneth Moss, MD; Syed Jaffery, MD; Luisa Bazan, MD; Laura Spear, RPSGT; Larry Darnell, RPSGT; Thomas Roth, PhD
Henry Ford Health System, Wayne State University, Detroit, Michigan

We report a case series of four patients where tachypnea was observed during positive airway titration studies, double the baseline breathing rate (tachypnea range 46–68 breaths/min). It happened mainly during non-rapid eye movement to rapid eye movement sleep transitions without significant changes in oxygen saturation or signs of autonomic hyperactivity such as an increased heart rate. The increased respiratory rate may be a normal physiological extreme outlier seen during phasic rapid eye movement sleep triggered by high pressure ventilation and it may also indicate underlying ventilatory instability, making patients predisposed to central sleep apnea.


Gupta A, Roehrs T, Moss K, Jaffery S, Bazan L, Spear L, Darnell L, Roth T. Tachypnea seen during positive airway pressure titration studies: a case series of four patients. J Clin Sleep Med. 2018;14(10):1801–1804.

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