ADVERTISEMENT

Issue Navigator

Volume 14 No. 10
Earn CME
Accepted Papers
Classifieds





Scientific Investigations

Uvulopalatopharyngoplasty May Reduce the Incidence of Dementia Caused by Obstructive Sleep Apnea: National Insurance Service Survey 2007–2014

Jae Hoon Cho, MD, PhD1; Jeffrey D. Suh, MD2; Kyung-Do Han3; Jin-Hyung Jung3; Heung Man Lee, MD, PhD4
1Department of Otorhinolaryngology-Head and Neck Surgery, Konkuk University College of Medicine, Seoul, Korea; 2Department of Head and Neck Surgery, UCLA School of Medicine, Los Angeles, California; 3Department of Biostatistics, Biomedicine and Health Sciences, Catholic University College of Medicine, Seoul, Korea; 4Department of Otorhinolaryngology-Head and Neck Surgery, Guro Hospital, Korea University College of Medicine, Seoul, Korea

Study Objectives:

Numerous studies have found that obstructive sleep apnea (OSA) causes or exacerbates dementia, including Alzheimer disease and vascular dementia. However, the evidence is often conflicting. Moreover, no study has investigated the effect of surgical treatment for OSA on dementia.

Methods:

This retrospective cohort study analyzed data from the Korea National Health Insurance Corporation. A total of 125,417 participants (age 40 years or older) with a new diagnosis of OSA between 2007 and 2014 were included. The participants were classified into two groups: those who underwent uvulopalatopharyngoplasty (UPPP group, n = 12,664) and those who underwent no surgical treatment (no surgery group, n = 112,753). Propensity score matching by age and sex was used to select the control group of 627,085 participants. Mean follow-up duration was 4.6 ± 2.3 years. The primary endpoint was newly diagnosed Alzheimer dementia, vascular dementia, or other types of dementia.

Results:

Compared with the control group, the hazard ratio (HR) and 95% confidence interval of dementia was calculated for patients with OSA. In the no-surgery group, the incidence of Alzheimer disease (HR 1.30 [1.22–1.38]), vascular dementia (HR 1.20 [1.05–1.36]), and other types of dementia (HR 1.35 [1.20–1.54]) was significantly higher than those among the control group. In the UPPP group, the incidence of Alzheimer disease (HR 1.08 [0.80–1.45]), vascular dementia (HR 0.58 [0.30–1.12]), and other types of dementia (HR 1.00 [0.57–1.77]) was similar to control levels.

Conclusions:

Uvulopalatopharyngoplasty may have a preventive effect on dementia in patients with OSA.

Citation:

Cho JH, Suh JD, Han KD, Jung JH, Lee HM. Uvulopalatopharyngoplasty may reduce the incidence of dementia caused by obstructive sleep apnea: National Insurance Service Survey 2007–2014. J Clin Sleep Med. 2018;14(10):1749–1755.




Please login to continue reading the full article

Subscribers to JCSM get full access to current and past issues of the JCSM.

Login to JCSM

Not a subscriber?

Join the American Academy of Sleep Medicine and receive a subscription to JCSM with your membership

Subscribe to JCSM:  $75/volume year for individuals or $140/volume year for institutions to access all current articles and archives published in JCSM.

Download this article*:   $20 to access a PDF version of a specific article from the current issue of JCSM.

*Purchase of an electronic download of JCSM provides permission to access and print the issue/article for personal scholarly, research and educational use. Please note: access to the article is from the computer on which the article is purchased ONLY. Purchase of the article does not permit distribution, electronic or otherwise, of the article without the written permission of the AASM. Further, purchase does not permit the posting of article text on an online forum or website.