The aim of this study is to detect the features of sleep disorder via polysomnography (PSG) based on Chinese pedigree of frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17).
Five members (two symptomatic patients and three patients with a presymptomatic mutation) from the FTDP-17 pedigree were enrolled, in comparison with 9 patients with Parkinson disease (PD) and 11 control patients. Each patient underwent standard PSG and hypnogram analysis.
Sleep architecture is affected in the presymptomatic stage of FTDP-17, including total sleep time and sleep efficiency. However, rapid eye movement sleep behavior disorder seems to be exempt from FTDP-17. In hypnogram analysis, five individuals with FTDP-17 exhibited decreased sleep efficiency and disruption of the normal cyclic sleep organization.
In FTDP-17, striatum and brainstem are the pathological lesions, which may be involved in the pathophysiology of the alterations in sleep architecture. The concrete mechanisms need further investigation.
Liu J, Zhan S, Huang C, Liu Y, Liu L, Wu L, Wang Y. Sleep architecture changed without RBD in patients with FTDP-17. J Clin Sleep Med. 2018;14(10):1735–1739.