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Volume 14 No. 10
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Scientific Investigations

Sleep Architecture Changed Without RBD in Patients With FTDP-17

Jia Liu, MD, PhD1; Shuqin Zhan, MD1; Chaoyang Huang, MD1; Yang Liu, MD1; Lin Liu, MD1; Liyong Wu, MD1,2; Yuping Wang, MD1
1Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China; 2National Clinical Research Center for Geriatric Disorders, Capital Medical University, Beijing, China

Study Objectives:

The aim of this study is to detect the features of sleep disorder via polysomnography (PSG) based on Chinese pedigree of frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17).

Methods:

Five members (two symptomatic patients and three patients with a presymptomatic mutation) from the FTDP-17 pedigree were enrolled, in comparison with 9 patients with Parkinson disease (PD) and 11 control patients. Each patient underwent standard PSG and hypnogram analysis.

Results:

Sleep architecture is affected in the presymptomatic stage of FTDP-17, including total sleep time and sleep efficiency. However, rapid eye movement sleep behavior disorder seems to be exempt from FTDP-17. In hypnogram analysis, five individuals with FTDP-17 exhibited decreased sleep efficiency and disruption of the normal cyclic sleep organization.

Conclusions:

In FTDP-17, striatum and brainstem are the pathological lesions, which may be involved in the pathophysiology of the alterations in sleep architecture. The concrete mechanisms need further investigation.

Citation:

Liu J, Zhan S, Huang C, Liu Y, Liu L, Wu L, Wang Y. Sleep architecture changed without RBD in patients with FTDP-17. J Clin Sleep Med. 2018;14(10):1735–1739.




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