ADVERTISEMENT

Issue Navigator

Volume 14 No. 09
Earn CME
Accepted Papers
Classifieds





Scientific Investigations

Vascular Response During Mental Stress in Sedentary and Physically Active Patients With Obstructive Sleep Apnea

Rosyvaldo Ferreira-Silva, MSc1; Thiago T. Goya, MSc2; Eline R.F. Barbosa, MD3; Bruno G. Durante, BS2; Carlos E.L. Araujo, BS2; Geraldo Lorenzi-Filho, MD, PhD3; Linda M. Ueno-Pardi, PhD1
1Universidade de São Paulo, Escola de Artes Ciencias e Humanidades, São Paulo, São Paulo, Brazil; 2Faculdade de Medicina, Universidade de São Paulo, São Paulo, São Paulo, Brazil; 3Instituto do Coração, Divisao de Pneumologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, São Paulo, Brazil

Study Objectives:

To compare vascular function of sedentary (SED) versus physically active (ACTIVE) patients with obstructive sleep apnea (OSA) during rest and mental stress.

Methods:

Patients with untreated OSA without other comorbidities were classified into SED and ACTIVE groups according to the International Physical Activity Questionnaire. Blood pressure (BP), heart rate (HR), forearm blood flow (FBF) (plethysmography), and forearm vascular conductance (FVC = FBF / mean BP × 100) were continuously measured at rest (4 minutes) followed by 3 minutes of mental stress (Stroop Color Word Test).

Results:

We studied 40 patients with OSA (men = 24, age = 50 ± 1 years, body mass index = 29.3 ± 0.5 kg/m2, apnea-hypopnea index = 39.3 ± 4 events/h). Leisure time physical activity domain in SED (n = 19) and ACTIVE (n = 21) was 20 ± 8 and 239 ± 32 min/wk, (P < .05). Baseline profile and perception of stress were similar in both groups. Baseline FBF (3.5 ± 0.2 mL/min/100 mL versus 2.4 ± 0.14 mL/min/100 mL) and FVC (3.5 ± 0.2 U versus 2.3 ± 0.1 U) were significantly lower in the SED group than in the ACTIVE group, respectively (P < .05). HR and BP increased similarly during mental stress test in both groups. Changes during mental stress in FBF (0.65 ± 0.12 versus 1.04 ± 0.12) and FVC (0.58 ± 0.11 versus 0.99 ± 0.11) were significantly lower in the SED group than in the ACTIVE group, respectively (P < .05). There was a significant correlation between leisure time physical activity and FBF (r = .57, P < .05) and FVC (r = .48, P < .05) during mental stress.

Conclusions:

The vascular response among patients with OSA is influenced by the level of physical activity. A high level of physical activity may partially protect against the cardiovascular dysfunction associated with OSA.

Citation:

Ferreira-Silva R, Goya TT, Barbosa ER, Durante BG, Araujo CE, Lorenzi-Filho G, Ueno-Pardi LM. Vascular response during mental stress in sedentary and physically active patients with obstructive sleep apnea. J Clin Sleep Med. 2018;14(9):1463–1470.




Please login to continue reading the full article

Subscribers to JCSM get full access to current and past issues of the JCSM.

Login to JCSM

Not a subscriber?

Join the American Academy of Sleep Medicine and receive a subscription to JCSM with your membership

Subscribe to JCSM:  $75/volume year for individuals or $140/volume year for institutions to access all current articles and archives published in JCSM.

Download this article*:   $20 to access a PDF version of a specific article from the current issue of JCSM.

*Purchase of an electronic download of JCSM provides permission to access and print the issue/article for personal scholarly, research and educational use. Please note: access to the article is from the computer on which the article is purchased ONLY. Purchase of the article does not permit distribution, electronic or otherwise, of the article without the written permission of the AASM. Further, purchase does not permit the posting of article text on an online forum or website.