ADVERTISEMENT

Issue Navigator

Volume 14 No. 03
Earn CME
Accepted Papers
Classifieds





Scientific Investigations

Symptom-Based Subgroups of Koreans With Obstructive Sleep Apnea

Jinyoung Kim, PhD, RN1,2; Brendan T. Keenan, MS2; Diane C. Lim, MD, MTR2,3,4; Seung Ku Lee, PhD5; Allan I. Pack, MB ChB, PhD2,3; Chol Shin, MD, PhD5,6
1University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania; 2Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania; 3Division of Sleep Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; 4Department of Medicine, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania; 5Institute of Human Genomic Study, Korea University Ansan Hospital, Ansan, Korea; 6School of Medicine, Korea University, Seoul, Korea

Study Objectives:

Recently, the Icelandic Sleep Apnea Cohort (ISAC) identified three subgroups in patients with obstructive sleep apnea (OSA) recruited from the sleep clinic based on clinical symptoms and comorbidities: excessively sleepy, minimally symptomatic, and disturbed sleep. This study sought to determine whether the three OSA subgroups are applicable to a population-based cohort in Korea.

Methods:

Study subjects are participants of an ongoing cohort study in Korea. Of the 2,918 participants, 422 new moderate to severe OSA cases (apneahypopnea index [AHI] ≥ 15 events/h) were diagnosed by home sleep studies. All participants completed a detailed questionnaire on sleep-related symptoms, comorbidities, medication, and other information. A latent class analysis was performed.

Results:

When examining solutions for up to 10 clusters, the a priori three-cluster solution was the optimal clustering solution. The three-cluster solution demonstrated a subgroup presentation similar to the clusters identified in the ISAC. The minimally symptomatic subgroup was most prevalent (55.7%) in the Korean cohort. Among the three subgroups, there were no differences in mean AHI and body mass index; however, the disturbed sleep subgroup was older and had more females.

Conclusions:

Combined with the ISAC data, we suggest that the three-symptom cluster solution for patients with OSA may be more widely applicable, irrespective of ethnicity and study population.

Citation:

Kim J, Keenan BT, Lim DC, Lee SK, Pack AI, Shin C. Symptom-based subgroups of koreans with obstructive sleep apnea. J Clin Sleep Med. 2018;14(3):437–443.




Please login to continue reading the full article

Subscribers to JCSM get full access to current and past issues of the JCSM.

Login to JCSM

Not a subscriber?

Join the American Academy of Sleep Medicine and receive a subscription to JCSM with your membership

Subscribe to JCSM:  $75/volume year for individuals or $140/volume year for institutions to access all current articles and archives published in JCSM.

Download this article*:   $20 to access a PDF version of a specific article from the current issue of JCSM.

*Purchase of an electronic download of JCSM provides permission to access and print the issue/article for personal scholarly, research and educational use. Please note: access to the article is from the computer on which the article is purchased ONLY. Purchase of the article does not permit distribution, electronic or otherwise, of the article without the written permission of the AASM. Further, purchase does not permit the posting of article text on an online forum or website.