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Volume 14 No. 02
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Accepted Papers

Scientific Investigations

Influence of Obstructive Sleep Apnea in the Functional Aspects of Patients With Osteoarthritis

Andressa Silva, PhD1; Marco Túlio Mello, PhD1; Paula Regina Serrão, PhD2; Roberta Pitta Luz, PhD3; Franciele Ruiz, PhD3; Lia Rita Bittencourt, PhD3; Sergio Tufik, PhD3; Stela Márcia Mattiello, PhD2
1Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil; 2Universidade Federal de São Carlos (UFSCAR), São Carlos, São Paulo, Brazil; 3Universidade Federal de São Paulo (UNIFESP), São Paulo, São Paulo, Brazil

Study Objectives:

It has been demonstrated in recent studies that obstructive sleep apnea (OSA) is the most prevalent sleep disorder in patients with osteoarthritis (OA), and thus the current study aimed to investigate the influence of OSA on knee extensor torque, pain, stiffness, and physical function in men with low-grade knee OA.


The study included 60 male volunteers, aged 40 to 70 years, allocated into four groups: Group 1 (G1) Control (n = 15): without OA and without OSA; Group 2 (G2) (n = 15): with OA and without OSA; Group 3 (G3) (n = 15): without OA and with OSA; and Group 4 (G4) (n = 15) with OA and with OSA.

All volunteers were examined using knee radiographs and polysomnography, responded to the Western Ontario McMaster Osteoarthritis Index (WOMAC) questionnaire, and completed a test on an isokinetic dynamometer to evaluate peak isometric knee extensor torque, both concentric and eccentric (90°/s and 180°/s).


Regarding the data from the WOMAC questionnaire (for pain, stiffness, and physical function), it was observed that G4 showed higher values compared to G1 or G3. For the concentric isometric and isokinetic peak knee extensor torque, lower values were observed in G4 compared to G1 or G3.


Patients who have knee OA in the early grades, when associated with OSA, have higher changes of the peak extensor torque, pain, stiffness, and physical function, compared with patients who did not have OSA.

Clinical Trial Registration:

Registry:, Identifier: NCT01422967, Title: Changes Of Sleep on the Sensoriomotor and Cytokine In Patients With Osteoarthritis, URL:


Silva A, Mello MT, Serrão PR, Luz RP, Ruiz F, Bittencourt LR, Tufik S, Mattiello SM. Influence of obstructive sleep apnea in the functional aspects of patients with osteoarthritis. J Clin Sleep Med. 2018;14(2):265–270.

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